Chemotherapy for pancreatic cancer often involves a combination of drugs. These combinations are used to increase the effectiveness of treatment by attacking the cancer cells in different ways. Here are some common drug combinations used in the treatment of pancreatic cancer:
- FOLFIRINOX: includes Fluorouracil (5-FU), Leucovorin, Irinotecan, and Oxaliplatin. This is a more aggressive treatment and is usually used for patients in good health with advanced pancreatic cancer.
- Gemcitabine and Nab-Paclitaxel (Abraxane): This combination is often used for the treatment of advanced pancreatic cancer. Gemcitabine is a chemotherapy drug that interferes with the process of DNA production in cells, thereby inhibiting their ability to reproduce. Nab-Paclitaxel is a newer form of the drug paclitaxel and works by interfering with the normal function of microtubules in the cell.
- Gemcitabine alone: For patients who might not tolerate combination chemotherapy, gemcitabine alone can be used. It’s less effective than combination therapies but also has fewer side effects.
- Gemcitabine and Erlotinib: Erlotinib is a targeted therapy drug that can be used in combination with gemcitabine for advanced pancreatic cancer.
The choice of chemotherapy regimen depends on several factors, including the type and stage of pancreatic cancer, the patient’s overall health, and the patient’s personal preferences. The potential benefits of each regimen must be weighed against the potential side effects. As always, these decisions should be made in consultation with a healthcare provider.